FGF2 (NM_002006) Human Recombinant Protein
Purified recombinant protein of Human fibroblast growth factor 2 (basic) (FGF2).
Product Datasheet for 'TP723110'
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|Description||Purified recombinant protein of Human fibroblast growth factor 2 (basic) (FGF2).|
|Expression cDNA Clone or AA Sequence||AAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS|
|Predicted MW||17.2 kDa|
|Concentration||Resuspend the protein in the desired concentration in proper buffer|
|Purity||>95% as determined by SDS-PAGE and Coomassie blue staining|
|Buffer||Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2|
|Bioactivity||Assay #1: ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is less than or equal to 0.5 ng/ml, corresponding to a specific activity of > 2 x 10^6 units/mg. Assay #2: ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is less than or equal to 0.1 ng/ml, corresponding to a specific activity of > 1 x 10^7 units/mg.|
|Endotoxin||Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).|
|Synonyms||BFGF; FGF-2; FGFB; HBGF-2|
|Summary||The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008].|
|Protein Families||Secreted Protein, Druggable Genome|
|Protein Pathways||MAPK signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Melanoma|