Activin Receptor Type IIA (ACVR2A) (NM_001616) Human Recombinant Protein

CAT#: TP721059

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Purified recombinant protein of Human activin A receptor, type IIA (ACVR2A)

  View other "ACVR2A" proteins (3)

USD 300.00

2 Weeks

    • 10 ug

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Product Data
Description Purified recombinant protein of Human activin A receptor, type IIA (ACVR2A)
Species Human
Expression Host HEK293
Tag C-Fc/His
Predicted MW 41.2 kDa
Concentration lot specific
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 µM filtered solution of 20mM PB, 150mM NaCl, pH 7.4
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Storage Store at -80°C.
Stability Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Reference Data
RefSeq NP_001607
Locus ID 92
Refseq Size 5244
Cytogenetics 2q22.3-q23.1
Refseq ORF 1539
Synonyms ACTRII; ACVR2
Summary This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, TGF-beta signaling pathway


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