LDL Receptor (LDLR) (NM_000527) Human Recombinant Protein
CAT#: TP720505
Recombinant protein of human low density lipoprotein receptor (LDLR), Ala22 - Arg788
Specifications
Product Data | |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence |
Ala22-Arg788
|
Tag | C-His |
Predicted MW | 86 kDa |
Concentration | lot specific |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Provided lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl |
Endotoxin | < 0.1 EU per µg protein as determined by LAL test |
Reconstitution | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in ddH2O. It is not recommended to reconstitute a concentration less than 100 µg/ml. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Storage | Store at -80°C. |
Stability | Stable for at least 3 months from date of receipt under proper storage and handling conditions. |
Reference Data | |
RefSeq | NP_000518 |
Locus ID | 3949 |
UniProt ID | P01130, A0A024R7D5 |
Cytogenetics | 19p13.2 |
Synonyms | FH; FHC; FHCL1; LDLCQ2 |
Summary | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
Protein Pathways | Endocytosis |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC400183 | LDLR HEK293T cell transient overexpression lysate (as WB positive control) |
USD 134.00 |
|
LC434371 | LDLR HEK293T cell transient overexpression lysate (as WB positive control) |
USD 206.00 |
|
LC434377 | LDLR HEK293T cell transient overexpression lysate (as WB positive control) |
USD 206.00 |
|
LY400183 | Transient overexpression lysate of low density lipoprotein receptor (LDLR) |
USD 436.00 |
|
LY434371 | Transient overexpression lysate of low density lipoprotein receptor (LDLR), transcript variant 6 |
USD 665.00 |
|
LY434377 | Transient overexpression lysate of low density lipoprotein receptor (LDLR), transcript variant 4 |
USD 665.00 |
|
PH300006 | LDLR MS Standard C13 and N15-labeled recombinant protein (NP_000518) |
USD 3,255.00 |
|
TP300006 | Recombinant protein of human low density lipoprotein receptor (LDLR), 20 µg |
USD 867.00 |
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