Integrin alpha 5 (ITGA5) (NM_002205) Human Recombinant Protein

CAT#: TP720399

Recombinant protein of human integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (ITGA5)

Product images

Specifications

Product Data

• Description: Recombinant protein of human integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (ITGA5)
• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence: A DNA sequence from TrueORF clone, RC201151, encoding the secreted form (Phe42-Tyr995) of human ITGA5
• Tag: N-GST
• Predicted MW: 105.1 kDa
• Concentration: lot specific
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.2.
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Storage: Store at -80°C.
• Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_002196
• Locus ID: 3678
• Refseq Size: 4267
• Cytogenetics: 12q13.13
• Refseq ORF: 3147
• Synonyms: CD49e; FNRA; VLA-5; VLA5A
• Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton