Junctional Adhesion Molecule 1 (F11R) (NM_016946) Human Recombinant Protein

CAT#: TP720393

Recombinant protein of human F11 receptor (F11R)

Product images

Specifications

Product Data

• Description: Recombinant protein of human F11 receptor (F11R)
• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence: A DNA sequence from TrueORF clone, RC221478, encoding the secreted form (Ser28-Val238) of human JAM-A
• Tag: Tag Free
• Predicted MW: 23.9 kDa
• Concentration: lot specific
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Lyophilized from a 0.2 µM filtered solution of 20mM Tris-HCl, 50mM NaCl, 100mM Glycine, pH 7.5.
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Storage: Store at -80°C.
• Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_058642
• Locus ID: 50848
• Refseq Size: 3660
• Cytogenetics: 1q23.3
• Refseq ORF: 897
• Synonyms: CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1
• Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Epithelial cell signaling in Helicobacter pylori infection, Leukocyte transendothelial migration, Tight junction