Angiotensin Converting Enzyme 2 (ACE2) (NM_021804) Human Recombinant Protein

CAT#: TP720353

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Recombinant secreted form of human ACE2 (Gln18 to Ser740)


Product Datasheet for 'TP720353'


  View other "ACE2" proteins (1)

USD 300.00


Availability*
2 Weeks

Size
    • 10 ug


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Specifications

Product Data
Description Recombinant secreted form of human ACE2 (Gln18 to Ser740)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC208442, encoding the secreted form (Gln18-Ser740) of human ACE-2
Tag C-His
Predicted MW 84.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer 20mM Tris-HCl, 150mM NaCl, 0.1mM ZnCl2, 10% Glycerol, pH 7.5.
Endotoxin < 0.1 EU per µg protein as determined by LAL test
Storage Store at -80°C.
Stability Stable for at least 3 months from date of receipt under proper storage and handling conditions.
Reference Data
RefSeq NP_068576
Locus ID 59272
Refseq Size 3519
Cytogenetics Xp22.2
Refseq ORF 2415
Synonyms ACEH
Summary The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2 (COVID-19 virus). [provided by RefSeq, Mar 2020]
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Renin-angiotensin system

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Other Versions

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