HMG1 (HMGB1) (NM_002128) Human Recombinant Protein

CAT#: TP720309

Recombinant protein of human high-mobility group box 1 (HMGB1)

Product Images

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  Autoantibodies against chloride intracellular channel 2 (CLIC2) and high mobility group box 1 (HMGB1) in sera from systemic lupus erythematosus patients (n = 43) versus healthy controls (n = 43) were detected in ELISA assays with CLIC2 (OriGene TP304727) and HMGB1 (OriGene TP720309) recombinant proteins. Figure cited from J Postgrad Med, PMID: 28862243

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Gly2-Glu215
• Tag: C-His
• Predicted MW: 25.9 kDa
• Concentration: lot specific
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Provided lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl
• Bioactivity: ELISA capture for autoantibodies (PMID: 28862243)
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Storage: Store at -80°C.
• Stability: Stable for at least 3 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_002119
• Locus ID: 3146
• UniProt ID: P09429, A0A024RDR0, Q5T7C3
• Cytogenetics: 13q12.3
• Synonyms: HMG-1; HMG1; HMG3; SBP-1
• Summary: This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]
• Protein Families: Druggable Genome, Stem cell - Pluripotency, Transcription Factors
• Protein Pathways: Base excision repair