Aldolase (ALDOA) (NM_000034) Human Recombinant Protein

CAT#: TP720179

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Recombinant protein of human aldolase A, fructose-bisphosphate (ALDOA), transcript variant 1

Product Datasheet for 'TP720179'

 Cited in 1 publication.

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USD 300.00

2 Weeks

    • 10 ug

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Product Data
Description Recombinant protein of human aldolase A, fructose-bisphosphate (ALDOA), transcript variant 1
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC202576, encoding the full length polypeptide (Met1-Tyr364) of human ALDOA
Tag C-His
Predicted MW 40.5 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer 20mM Tris-HCl, 100mM NaCl, 20% Glycerol, pH 8.0.
Bioactivity Enzyme activity regulator (PMID: 29084207)
Endotoxin < 0.1 EU per µg protein as determined by LAL test
Reference Data
RefSeq NP_000025
Locus ID 226
Refseq Size 2408
Cytogenetics 16p11.2
Refseq ORF 1092
Synonyms ALDA; GSD12; HEL-S-87p
Summary This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]
Protein Families Druggable Genome
Protein Pathways Fructose and mannose metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Pentose phosphate pathway

Citations (1)


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