OGG1 (NM_002542) Human Recombinant Protein

CAT#: TP720109

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Recombinant protein of human 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 1a



  View other "OGG1" proteins (11)

USD 300.00


Availability*
2 Weeks

Size
    • 10 ug


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Specifications

Product Data
Description Recombinant protein of human 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 1a
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC200522, encoding the polypeptide (Met1-Gly345) of human DNA Lyase
Tag Tag Free
Predicted MW 65.1 kDa
Concentration lot specific
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer 20mM Tris-HCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.
Endotoxin < 0.1 EU per µg protein as determined by LAL test
Storage Store at -80°C.
Stability Stable for at least 3 months from date of receipt under proper storage and handling conditions.
Reference Data
RefSeq NP_002533
Locus ID 4968
Refseq Size 1652
Cytogenetics 3p25.3
Refseq ORF 1035
Synonyms HMMH; HOGG1; MUTM; OGH1
Summary This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]
Protein Families Druggable Genome
Protein Pathways Base excision repair

Citations (1)

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