IL17(IL17A) (NM_002190) Human Recombinant Protein

CAT#: TP720016

Recombinant protein of human interleukin 17A (IL17A)


 Product Datasheet for 'TP720016'

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USD 299.00


Availability*
5 Days

Size
    • 10 ug

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Specifications

Product Data
Description Recombinant protein of human interleukin 17A (IL17A)
Species Human
Expression Host E.Coli
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC218057, encoding the mature peptide (Gly24-Ala155) of human IL17A
Tag Tag Free
Predicted MW 15.7 kDa
Concentration Resuspend the protein to the desired concentration in proper buffer.
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, pH 7.4. Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Bioactivity ED50 is approximately 2 ng/ml as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts. Specific Activity of 5 x 105 IU/mg.
Endotoxin < 0.1 EU per µg protein as determined by LAL test
Reference Data
RefSeq NP_002181
Locus ID 3605
Refseq Size 1859
Cytogenetics 6p12.2
Refseq ORF 465
Synonyms CTLA8; IL-17; IL-17A; IL17
Summary The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
Protein Families Secreted Protein, Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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