IL17 (IL17A) (NM_002190) Human Recombinant Protein

CAT#: TP720016

Recombinant protein of human interleukin 17A (IL17A)

Product images

Specifications

Product Data

• Description: Recombinant protein of human interleukin 17A (IL17A)
• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence: A DNA sequence from TrueORF clone, RC218057, encoding the mature peptide (Gly24-Ala155) of human IL17A
• Tag: Tag Free
• Predicted MW: 15.7 kDa
• Concentration: lot specific
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, pH 7.4.
• Bioactivity: ED50 is approximately 2 ng/ml as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts. Specific Activity of 5 x 105 IU/mg.
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Storage: Store at -80°C.
• Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_002181
• Locus ID: 3605
• Refseq Size: 1859
• Cytogenetics: 6p12.2
• Refseq ORF: 465
• Synonyms: CTLA-8; CTLA8; IL-17; IL-17A; IL17
• Summary: This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020]
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction