IL17(IL17A) (NM_002190) Human Recombinant Protein
CAT#: TP720016
Recombinant protein of human interleukin 17A (IL17A)
Product Datasheet for 'TP720016'
View other "IL17A" proteins (7)
Specifications
Product Data | |
Description | Recombinant protein of human interleukin 17A (IL17A) |
Species | Human |
Expression Host | E.Coli |
Expression cDNA Clone or AA Sequence | A DNA sequence from TrueORF clone, RC218057, encoding the mature peptide (Gly24-Ala155) of human IL17A |
Tag | Tag Free |
Predicted MW | 15.7 kDa |
Concentration | Resuspend the protein to the desired concentration in proper buffer. |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, pH 7.4. Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Bioactivity | ED50 is approximately 2 ng/ml as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts. Specific Activity of 5 x 105 IU/mg. |
Endotoxin | < 0.1 EU per µg protein as determined by LAL test |
Reference Data | |
RefSeq | NP_002181 |
Locus ID | 3605 |
Refseq Size | 1859 |
Cytogenetics | 6p12.2 |
Refseq ORF | 465 |
Synonyms | CTLA8; IL-17; IL-17A; IL17 |
Summary | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] |
Protein Families | Secreted Protein, Druggable Genome |
Protein Pathways | Cytokine-cytokine receptor interaction |
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Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
TP723780 | Purified recombinant protein of Human interleukin 17A and 17F (IL17A / IL-17F) heterodimer |
USD 355.00 |
|
LC400795 | IL17A HEK293T cell transient overexpression lysate (as WB positive control) |
USD 95.00 |
|
PH318057 | IL17A MS Standard C13 and N15-labeled recombinant protein (NP_002181) |
USD 1,995.00 |
|
LY400795 | Transient overexpression lysate of interleukin 17A (IL17A) |
USD 315.00 |
|
TP723711 | Purified recombinant protein of Human interleukin 17A (IL17A) |
USD 195.00 |
|
TP318057 | Recombinant protein of human interleukin 17A (IL17A) |
USD 748.00 |
|
TP723199 | Purified recombinant protein of Human interleukin 17A (IL17A). |
USD 230.00 |