IL17(IL17A) (NM_002190) Human Recombinant Protein

CAT#: TP720016

Product images

Specifications

Product Data

• Description: Recombinant protein of human interleukin 17A (IL17A)
• Species: Human
• Expression Host: E.Coli
• Expression cDNA Clone or AA Sequence: A DNA sequence from TrueORF clone, RC218057, encoding the mature peptide (Gly24-Ala155) of human IL17A
• Tag: Tag Free
• Predicted MW: 15.7 kDa
• Concentration: Resuspend the protein to the desired concentration in proper buffer.
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, pH 7.4. Stable for at least 6 months from date of receipt under proper storage and handling conditions.
• Bioactivity: ED50 is approximately 2 ng/ml as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts. Specific Activity of 5 x 105 IU/mg.
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test

Reference Data

• RefSeq: NP_002181
• Locus ID: 3605
• Refseq Size: 1859
• Cytogenetics: 6p12.2
• Refseq ORF: 465
• Synonyms: CTLA8; IL-17; IL-17A; IL17
• Summary: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
• Protein Families: Secreted Protein, Druggable Genome
• Protein Pathways: Cytokine-cytokine receptor interaction

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