VEGF Receptor 2 (KDR) (NM_002253) Human Recombinant Protein

CAT#: TP710249

Purified recombinant protein of Human kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR), residues 834–1162 aa, with C-terminal DDK tag, expressed in sf9, 20ug


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USD 515.00

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Size
    • 20 ug

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Frequently bought together (1)
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Specifications

Product Data
Species Human
Expression Host Sf9
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC219851, the region(Met-Leu834-Lys1162) of Homo sapiens KDR
Tag C-DDK
Predicted MW 37.2 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50 mM Tris-HCl, 100 mM glycine, pH 8.0, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_002244
Locus ID 3791
UniProt ID P35968
Cytogenetics 4q12
Refseq Size 6055
Refseq ORF 4068
Synonyms CD309; FLK1; VEGFR; VEGFR2
Summary Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion, VEGF signaling pathway

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