LYRIC (MTDH) (NM_178812) Human Recombinant Protein

CAT#: TP710116

Recombinant protein of human metadherin (MTDH), residues 70-582aa, with N-terminal His tag,expressed in sf9 cells

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: Sf9
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence from TrueORF clone, RC207238, encoding the region(Met-Gly70-Thr582) of Homo sapiens MTDH
• Tag: N-His
• Predicted MW: 56.3 kDa
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50 mM Tris-HCl, 100 mM glycine, pH 8.0, 10% glycerol
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_848927
• Locus ID: 92140
• UniProt ID: Q86UE4, A0A024R9D2
• Cytogenetics: 8q22.1
• Refseq Size: 7667
• Refseq ORF: 1746
• Synonyms: 3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3
• Summary: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.[UniProtKB/Swiss-Prot Function]
• Protein Families: Transmembrane