FLT3 (NM_004119) Human Recombinant Protein

CAT#: TP710100

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Recombinant protein of human fms-related tyrosine kinase 3 (FLT3), residues 27-543aa, with C-terminal DDK tag, expressed in sf9, 20ug


Product Datasheet for 'TP710100'


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USD 425.00


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    • 20 ug


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Product Data
Description Recombinant protein of human fms-related tyrosine kinase 3 (FLT3), residues 27-543aa, with C-terminal DDK tag, expressed in sf9, 20ug
Species Human
Expression Host Sf9
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC211459, encoding the region(Met-Asn27-Ser543) of Homo sapiens FLT3
Tag C-DDK
Predicted MW 58.3 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_004110
Locus ID 2322
Refseq Size 3475
Cytogenetics 13q12.2
Refseq ORF 2979
Synonyms CD135; FLK-2; FLK2; STK1
Summary This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
Protein Pathways Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer

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