EP300 (NM_001429) Human Recombinant Protein

CAT#: TP710007

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Recombinant protein of human E1A binding protein p300 (EP300),residues 1066-1707,with C-terminal DDK tag,expressed in sf9 cells



  View other "EP300" proteins (2)

USD 425.00


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    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human E1A binding protein p300 (EP300),residues 1066-1707,with C-terminal DDK tag,expressed in sf9 cells
Species Human
Expression Host Sf9
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC223265, encoding E1A binding domain(Tyr1066-Lys1707)of human EP300
Tag C-DDK
Predicted MW 75 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_001420
Locus ID 2033
Refseq Size 8765
Cytogenetics 22q13.2
Refseq ORF 7242
Synonyms KAT3B; MKHK2; p300; RSTS2
Summary This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Adherens junction, Cell cycle, Huntington's disease, Jak-STAT signaling pathway, Long-term potentiation, Melanogenesis, Notch signaling pathway, Pathways in cancer, Prostate cancer, Renal cell carcinoma, TGF-beta signaling pathway, Wnt signaling pathway

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