Thyroid Peroxidase (TPO) (NM_000547) Human Recombinant Protein

CAT#: TP701028

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Purified recombinant protein of human thyroid peroxidase (TPO), transcript variant 1, His tag, secretory expressed in HEK cells, 20ug


 Product Datasheet for 'TP701028'

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USD 748.00


Availability*
2 Weeks

Size
    • 20 ug


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Specifications

Product Data
Description Purified recombinant protein of human thyroid peroxidase (TPO), transcript variant 1, His tag, secretory expressed in HEK cells, 20ug
Species Human
Expression Host HEK293
Tag C-His
Predicted MW 92.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 90% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS, pH7.4.
Reference Data
RefSeq NP_000538
Locus ID 7173
Refseq Size 3152
Cytogenetics 2p25.3
Refseq ORF 2799
Synonyms MSA; TDH2A; TPX
Summary This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway, Metabolic pathways, Tyrosine metabolism

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