Bone Sialoprotein (IBSP) (NM_004967) Human Recombinant Protein

CAT#: TP700289

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Purified recombinant protein of human integrin-binding sialoprotein (IBSP), with C-terminal DDK/His tag, expressed in human cells;


 Product Datasheet for 'TP700289'

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USD 748.00


Availability*
2 Weeks

Size
    • 20 ug


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Specifications

Product Data
Description Purified recombinant protein of human integrin-binding sialoprotein (IBSP), with C-terminal DDK/His tag, expressed in human cells;
Species Human
Expression Host HEK293
Tag C-DDK/6xHis
Predicted MW 35.5 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS, pH7.4, 10% glycerol
Reference Data
RefSeq NP_004958
Locus ID 3381
Refseq Size 1108
Cytogenetics 4q22.1
Refseq ORF 951
Synonyms BNSP; BSP; BSP-II; SP-II
Summary The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways ECM-receptor interaction, Focal adhesion

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Other Versions

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