Insulin Receptor (INSR) (NM_000208) Human Recombinant Protein

CAT#: TP700110

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Purified recombinant protein of Human insulin receptor, transcript variant 1, with C-terminal DDK/His tag, expressed in human cells



  View other "INSR" proteins (4)

USD 748.00


Availability*
2 Weeks

Size
    • 20 ug


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Specifications

Product Data
Description Purified recombinant protein of Human insulin receptor, transcript variant 1, with C-terminal DDK/His tag, expressed in human cells
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC600010, encoding the extracellular domain (Ser763-Lys956) of human INSRv1
Tag C-DDK/His
Predicted MW 25 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS, pH7.4, 10% glycerol
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000199
Locus ID 3643
Refseq Size 9059
Cytogenetics 19p13.2
Refseq ORF 663
Synonyms CD220; HHF5
Summary This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Adherens junction, Insulin signaling pathway, Type II diabetes mellitus

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