Cytochrome P450 2C9 (CYP2C9) (NM_000771) Human Recombinant Protein

CAT#: TP320997

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Recombinant protein of human cytochrome P450, family 2, subfamily C, polypeptide 9 (CYP2C9)


 Product Datasheet for 'TP320997'

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USD 788.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human cytochrome P450, family 2, subfamily C, polypeptide 9 (CYP2C9)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 55.4 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000762
Locus ID 1559
Refseq Size 1835
Cytogenetics 10q23.33
Refseq ORF 1470
Synonyms CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, P450
Protein Pathways Arachidonic acid metabolism, Drug metabolism - cytochrome P450, Linoleic acid metabolism, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Retinol metabolism

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