CAMK2A (NM_015981) Human Recombinant Protein
Recombinant protein of human calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 1
Product Datasheet for 'TP318186'
Specifications
Product Data | |
Description | Recombinant protein of human calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 1 |
Species | Human |
Expression Host | HEK293T |
Tag | C-Myc/DDK |
Predicted MW | 55.1 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Bioactivity | Enzyme activity regulator (PMID: 29486595) |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Reference Data | |
RefSeq | NP_057065 |
Locus ID | 815 |
Refseq Size | 4836 |
Cytogenetics | 5q32 |
Refseq ORF | 1467 |
Synonyms | CAMKA; CaMKIINalpha; MRD53; MRT63 |
Summary | The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018] |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Calcium signaling pathway, ErbB signaling pathway, Glioma, GnRH signaling pathway, Long-term potentiation, Melanogenesis, Neurotrophin signaling pathway, Olfactory transduction, Oocyte meiosis, Wnt signaling pathway |
Citations (1)
The use of this Proteins has been cited in the following citations: |
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Critical roles of Carbon Monoxide and Nitric Oxide in Ca2+ Signaling for Insulin Secretion in Pancreatic Islets
,Rahman, FU;Park, DR;Joe, Y;Jang, KY;Chung, HT;Kim, UH;,
Antioxid. Redox Signal. 2018
,PubMed ID 29486595
[CAMK2A]
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Documents
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Resources
Protein Resources |
Other Versions
SKU | Description | Size | Price |
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PH305202 | CAMK2A MS Standard C13 and N15-labeled recombinant protein (NP_741960) |
USD 1,995.00 |
|
TP305202 | Recombinant protein of human calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 2 |
USD 748.00 |
|
LC406882 | CAMK2A HEK293T cell transient overexpression lysate (as WB positive control) |
USD 95.00 |
|
LC414271 | Transient overexpression lysate of calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 1 |
USD 55.00 |
|
PH318186 | CAMK2A MS Standard C13 and N15-labeled recombinant protein (NP_057065) |
USD 1,995.00 |
|
LY406882 | Transient overexpression lysate of calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 2 |
USD 315.00 |
USD 299.00
USD 375.00