PTGIS (NM_000961) Human Recombinant Protein

CAT#: TP311030

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Recombinant protein of human prostaglandin I2 (prostacyclin) synthase (PTGIS)


 Product Datasheet for 'TP311030'

 Cited in 1 publication.

  View other "PTGIS" proteins (3)

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human prostaglandin I2 (prostacyclin) synthase (PTGIS)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 56.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Bioactivity Enzyme substrate (PMID: 28013348)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000952
Locus ID 5740
Refseq Size 5603
Cytogenetics 20q13.13
Refseq ORF 1500
Synonyms CYP8; CYP8A1; PGIS; PTGI
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, P450, Transmembrane
Protein Pathways Arachidonic acid metabolism, Metabolic pathways

Citations (1)

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Other Versions

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