PTGIS (NM_000961) Human Recombinant Protein
Recombinant protein of human prostaglandin I2 (prostacyclin) synthase (PTGIS)
Specifications
Product Data | |
Description | Recombinant protein of human prostaglandin I2 (prostacyclin) synthase (PTGIS) |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence | Recombinant protein was produced with TrueORF clone, RC211030. Click on the TrueORF clone link to view cDNA and protein sequences. |
Tag | C-Myc/DDK |
Predicted MW | 56.9 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Bioactivity | Enzyme substrate (PMID: 28013348) |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_000952 |
Locus ID | 5740 |
Refseq Size | 5603 |
Cytogenetics | 20q13.13 |
Refseq ORF | 1500 |
Synonyms | CYP8; CYP8A1; PGIS; PTGI |
Summary | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome, P450, Transmembrane |
Protein Pathways | Arachidonic acid metabolism, Metabolic pathways |
Citations (1)
The use of this Proteins has been cited in the following citations: |
---|
Calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice
,Randriamboavonjy, V;Kyselova, A;Elgheznawy, A;Zukunft, S;Wittig, I;Fleming, I;,
Basic Res. Cardiol 2017
,PubMed ID 28013348
[PTGIS]
|
Documents
FAQs |
SDS |
Resources
Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC400347 | PTGIS HEK293T cell transient overexpression lysate (as WB positive control) |
USD 110.00 |
|
LY400347 | Transient overexpression lysate of prostaglandin I2 (prostacyclin) synthase (PTGIS) |
USD 360.00 |
|
PH311030 | PTGIS MS Standard C13 and N15-labeled recombinant protein (NP_000952) |
USD 2,260.00 |
USD 350.00
USD 345.00