Nucleoside phosphorylase (PNP) (NM_000270) Human Recombinant Protein

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human nucleoside phosphorylase (NP)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 31.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Bioactivity WB standard (PMID: 28251649)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000261
Locus ID 4860
Refseq Size 2438
Cytogenetics 14q11.2
Refseq ORF 867
Synonyms NP; PRO1837; PUNP
Summary This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Metabolic pathways, Nicotinate and nicotinamide metabolism, Purine metabolism, Pyrimidine metabolism

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