Natriuretic Peptide Receptor A (NPR1) (NM_000906) Human Recombinant Protein

CAT#: TP309267

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Recombinant protein of human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1)


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USD 788.00


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    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 118.7 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000897
Locus ID 4881
Refseq Size 4201
Cytogenetics 1q21.3
Refseq ORF 3183
Synonyms ANPa; ANPRA; GUC2A; GUCY2A; NPRA
Summary Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively). [supplied by OMIM, May 2009]
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Purine metabolism, Vascular smooth muscle contraction

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