Cytochrome P450 17A1 (CYP17A1) (NM_000102) Human Recombinant Protein

CAT#: TP309042

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Recombinant protein of human cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1)


 Product Datasheet for 'TP309042'

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USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 57.2 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000093
Locus ID 1586
Refseq Size 1755
Cytogenetics 10q24.32
Refseq ORF 1524
Synonyms CPT7; CYP17; P450C17; S17AH
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, P450
Protein Pathways C21-Steroid hormone metabolism, Metabolic pathways

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