alpha Tubulin (TUBA1A) (NM_006009) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 50 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_006000 |
| Locus ID | 7846 |
| UniProt ID | Q71U36 |
| Cytogenetics | 12q13.12 |
| RefSeq Size | 1930 |
| RefSeq ORF | 1353 |
| Synonyms | B-ALPHA-1; LIS3; TUBA3 |
| Summary | Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. provided by RefSeq, Jul 2017 |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Gap junction, Pathogenic Escherichia coli infection |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Other "alpha Tubulin" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH308669 | TUBA1A MS Standard C13 and N15-labeled recombinant protein (NP_006000) | 10 ug |
$3,360.00
|
|
| LC416932 | Lyophilized TUBA1A HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY416932 | Transient overexpression lysate of tubulin, alpha 1a (TUBA1A) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
Cross-talk between CDK4/6 and SMYD2 regulates gene transcription, tubulin methylation, and ciliogenesis
Li, Zhou, Wang et al
Sci Adv (2020) 6 (44) DOI: 10.1126/sciadv.abb3154
Li, Zhou, Wang et al
Sci Adv (2020) 6 (44) DOI: 10.1126/sciadv.abb3154
Cited by 51
AI Summary: OriGene’s recombinant α-tubulin (TUBA1A) protein was used as a substrate in in vitro assays to demonstrate SMYD2-mediated tubulin methylation, supporting the study’s findings on the role of CDK4/6-SMYD2 signaling in microtubule dynamics and ciliogenesis.
Snippet: In parallel, the purified GST-Smyd2 fusion proteins were incubated with 1 g of recombinant -tubulin (TUBA1A) protein (Origene). Following washing using PBST, the protein complexes were run on SDS-PAGE gels. Immunoblot analyses were performed using a mouse anti–-tubulin antibody (Santa Cruz Biotechnology)
Showing 1-1 of 1 papers.
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