Prothrombin (F2) (NM_000506) Human Recombinant Protein

CAT#: TP308589

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Recombinant protein of human coagulation factor II (thrombin) (F2)


 Product Datasheet for 'TP308589'

 Cited in 1 publication.

  View other "F2" proteins (6)

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human coagulation factor II (thrombin) (F2)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 67.5 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Bioactivity MS digestion standard (PMID: 29702392)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000497
Locus ID 2147
Refseq Size 2018
Cytogenetics 11p11.2
Refseq ORF 1866
Synonyms PT; RPRGL2; THPH1
Summary Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton

Citations (1)

Documents

Other Versions

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