CYP46 (CYP46A1) (NM_006668) Human Recombinant Protein

CAT#: TP305446

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Recombinant protein of human cytochrome P450, family 46, subfamily A, polypeptide 1 (CYP46A1)


 Product Datasheet for 'TP305446'

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USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human cytochrome P450, family 46, subfamily A, polypeptide 1 (CYP46A1)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 56.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_006659
Locus ID 10858
Refseq Size 2138
Cytogenetics 14q32.2
Refseq ORF 1500
Synonyms CP46; CYP46
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, P450
Protein Pathways Primary bile acid biosynthesis

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