HIPPI (IFT57) (NM_018010) Human Recombinant Protein

CAT#: TP304116

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Recombinant protein of human intraflagellar transport 57 homolog (Chlamydomonas) (IFT57)


 Product Datasheet for 'TP304116'

  View other "IFT57" proteins (3)

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human intraflagellar transport 57 homolog (Chlamydomonas) (IFT57)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 48.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_060480
Locus ID 55081
Refseq Size 3223
Cytogenetics 3q13.12-q13.13
Refseq ORF 1287
Synonyms ESRRBL1; HIPPI; MHS4R2; OFD18
Summary Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. [UniProtKB/Swiss-Prot Function]
Protein Families Druggable Genome
Protein Pathways Huntington's disease

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Other Versions

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