Seladin 1 (DHCR24) (NM_014762) Human Recombinant Protein

CAT#: TP303507

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Recombinant protein of human 24-dehydrocholesterol reductase (DHCR24)


 Product Datasheet for 'TP303507'

  View other "DHCR24" proteins (3)

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human 24-dehydrocholesterol reductase (DHCR24)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 57.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_055577
Locus ID 1718
Refseq Size 4286
Cytogenetics 1p32.3
Refseq ORF 1548
Synonyms DCE; Nbla03646; seladin-1; SELADIN1
Summary This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Stem cell - Pluripotency, Transmembrane
Protein Pathways Metabolic pathways, Steroid biosynthesis

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