MYL12B (NM_033546) Human Recombinant Protein
Recombinant protein of human myosin, light chain 12B, regulatory (MYL12B), transcript variant 2
Product Datasheet for 'TP301372'
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|Description||Recombinant protein of human myosin, light chain 12B, regulatory (MYL12B), transcript variant 2|
|Expression cDNA Clone or AA Sequence||Recombinant protein was produced with TrueORF clone, RC201372. Click on the TrueORF clone link to view cDNA and protein sequences.|
|Predicted MW||19.6 kDa|
|Concentration||>50 ug/mL as determined by microplate BCA method|
|Purity||> 80% as determined by SDS-PAGE and Coomassie blue staining|
|Buffer||25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. Store at –80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.|
|Summary||The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008].|
|Protein Pathways||Focal adhesion, Tight junction, Leukocyte transendothelial migration, Regulation of actin cytoskeleton|