Adenylosuccinate Lyase(ADSL) (NM_000026) Human Recombinant Protein

CAT#: TP300524

Recombinant protein of human adenylosuccinate lyase (ADSL), transcript variant 1

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 Product Datasheet for 'TP300524'

USD 438.00

USD 730.00


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Size
    • 20 ug

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Specifications

Product Data
Description Recombinant protein of human adenylosuccinate lyase (ADSL), transcript variant 1
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC200524. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-MYC/DDK
Predicted MW 54.7 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Reference Data
RefSeq NP_000017
Locus ID 158
Refseq Size 1692
Cytogenetics 22q13.1
Refseq ORF 1452
Synonyms AMPS; ASASE; ASL
Summary The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Protein Families
Protein Pathways
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