Junctional Adhesion Molecule 1(F11R) (NM_144504) Human Recombinant Protein
CAT#: TP300004
Recombinant protein of human F11 receptor (F11R), transcript variant 5
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Product Datasheet for 'TP300004'
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USD 730.00
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Product Data | |
Description | Recombinant protein of human F11 receptor (F11R), transcript variant 5 |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence | Recombinant protein was produced with TrueORF clone, RC200004. Click on the TrueORF clone link to view cDNA and protein sequences. |
Tag | C-MYC/DDK |
Predicted MW | 29.8 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Reference Data | |
RefSeq | NP_653087 |
Locus ID | 50848 |
Refseq Size | 3794 |
Cytogenetics | 1q23.3 |
Refseq ORF | 897 |
Synonyms | JAM, KAT, JAM1, JAMA, JCAM, CD321, JAM-1, JAM-A, PAM-1 |
Summary | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008] |
Protein Families | Transmembrane, Druggable Genome |
Protein Pathways | Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, Epithelial cell signaling in Helicobacter pylori infection |
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