Junctional Adhesion Molecule 1(F11R) (NM_144504) Human Recombinant Protein

Specifications

Product Data
Description	Recombinant protein of human F11 receptor (F11R), transcript variant 5
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	Recombinant protein was produced with TrueORF clone, RC200004. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag	C-MYC/DDK
Predicted MW	29.8 kDa
Concentration	>50 ug/mL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Reference Data
RefSeq	NP_653087
Locus ID	50848
Refseq Size	3794
Cytogenetics	1q23.3
Refseq ORF	897
Synonyms	JAM, KAT, JAM1, JAMA, JCAM, CD321, JAM-1, JAM-A, PAM-1
Summary	Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
Protein Families	Transmembrane, Druggable Genome
Protein Pathways	Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, Epithelial cell signaling in Helicobacter pylori infection

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