Alpha-Synuclein / SNCA (1-60) Human Protein

CAT#: SA6008

Alpha-Synuclein / SNCA (1-60) human recombinant protein, 0.1 mg


USD 338.00

3 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK
Predicted MW 6.149 kDa
Concentration lot specific
Purity >95% by SDS-PAGE
Presentation Purified
Buffer Presentation State: Purified
State: Liquid protein
Buffer System: 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl
Preparation Liquid protein
Protein Description A deletion mutant of alpha-synuclein (amino acids 1-60), which contains the N-terminal amphipathic domain.Syn1-60 was overexpressed in E. coli and the recombinant protein was purified to apparent homogeneity by using conventional column chromatography techniques.
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000336
Locus ID 6622
UniProt ID P37840
Cytogenetics 4q22.1
Synonyms NACP; PARK1; PARK4; PD1
Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Parkinson's disease

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.