Alpha-Synuclein / SNCA (1-140) Human Protein

CAT#: SA6001XFD

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Alpha-Synuclein / SNCA (1-140) human recombinant protein, 1 mg


Product Datasheet for 'SA6001XFD'


USD 590.00


Availability*
2 Weeks

Size
    • 1 mg


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Specifications

Product Data
Description Alpha-Synuclein / SNCA (1-140) human recombinant protein, 1 mg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Predicted MW 14.46 kDa
Purity >95%
Buffer Presentation State: Purified
State: Lyophilized from a 0.2 um filtered solution
Buffer System: 20 mM Tris-HCl buffer (pH 7.5), 100 mM NaCl, 1mM MgCl2
Endotoxin < 1.0 EU per 1 ug of protein (determined by LAL method)
Reconstitution Restore in sterile distilled water to a concentration of 1 mg/ml or less.
Preparation Lyophilized from a 0.2 um filtered solution
Protein Description Purified human recombinant alpha-Synuclein (amino acids 1-140).
Storage Upon receipt, store it immediately at 2-8°C for up to one month. For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch
Reference Data
RefSeq NP_000336
Locus ID 6622
Cytogenetics 4q22.1
Synonyms NACP; PARK1; PARK4; PD1
Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Parkinson's disease

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