Collagen type IV Human Protein

Collagen type IV human protein, 0.5 mg

USD 480.00

5 Days

    • 500 ug

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Product Data
Description Collagen type IV human protein, 0.5 mg
Species Human
Protein Source Placenta
Concentration 1.0 mg/ml (by dry weight)
Purity Chromatographically and Immunologically pure.
Buffer State: Liquid (sterile filtered) purified protein
Buffer System: 0.5M Acetic Acid
Preservative: 0.01% Sodium Azide
Stabilizer: None
Preparation Liquid (sterile filtered) purified protein
Applications ELISA.
Suitable for use as a Control or standard in indirect trapping ELISA for quantitation of antigen in serum using a standard curve.
Western blotting.
Protein Description This antigen is free from other Collagens, Human serum proteins and non-Collagen extracellular matrix proteins and reacts with anti-Collagen Type IV.
Reaction with anti-Collagen I, II, III, V or VI is negligible (typically less than 1% cross reactivity was detected by ELISA).
Note Caution: No test method can provide total assurance that the hepatitis B virus, hepatitis C virus, human immunodeficiency virus, or any other infectious agents are absent. Thus, all blood products, including purified proteins derived from human blood sources, should be handled at Biosafety Level 2 as recommended by the CDCNIH manual entitled Biosafety in Microbiological and Biomedical Laboratories for potentially infectious human serum, blood specimens or proteins derived from same.
Source material for the human blood product supplied to your facility has been tested for the detection of HIV antibody, Hepatitis B surface antigen, antibody to Hepatitis C, HIV 1 antigen(s), antibody to HTLV - I/II, and syphilis by FDA guidelines. All units were found to be non-reactive/negative for these tests. All human blood source material is collected in FDA licensed centers and is tested with FDA approved test kits.
Storage Store vial at 2-8°C prior to opening.
This product is stable 2-8°C as an undiluted liquid.
Dilute only prior to immediate use.
Stability Shelf life: 6 months from despatch.
Reference Data
RefSeq NP_001290039
Locus ID 1282
Cytogenetics 13q34
Summary This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Protein Pathways ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer


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