Collagen type IV

This antigen is free from other Collagens, Human serum proteins and non-Collagen extracellular matrix proteins and reacts with anti-Collagen Type IV.
Reaction with anti-Collagen I, II, III, V or VI is negligible (typically less than 1% cross reactivity was detected by ELISA).


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USD 450.00


Availability*
5 Days

Size
    • 500 ug


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Specifications

Product Data
Description This antigen is free from other Collagens, Human serum proteins and non-Collagen extracellular matrix proteins and reacts with anti-Collagen Type IV.
Reaction with anti-Collagen I, II, III, V or VI is negligible (typically less than 1% cross reactivity was detected by ELISA).
Species Human
Expression Host Placenta
Concentration 1.0 mg/ml (by dry weight)
Purity Chromatographically and Immunologically pure.
Buffer 0.5M Acetic Acid
Preparation Liquid (sterile filtered) purified protein
Reference Data
RefSeq NP_001290039
Locus ID 1282
Cytogenetics 13q34
Synonyms BSVD; BSVD1; RATOR
Summary This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Protein Pathways ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer

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68 Mouse Clones