Adiponectin (biologically active)
Product Datasheet for 'PA502X'
|Expression cDNA Clone or AA Sequence||EDDVTTTEEL APALVPPPKG TCAGWMAGIP GHPGHNGTPG RDGRDGTPGE KGEKGDAGLL GPKGETGDVG MTGAEGPRGF PGTPGRKGEP GEAAYMYRSA FSVGLETRVT VPNVPIRFTK IFYNQQNHYD GSTGKFYCNI PGLYYFSYHI TVYMKDVKVS LFKKDKAVLF TYDQYQEKNV DQASGSVLLH LEVGDQVWLQ VYGDGDHNGL YADNVNDSTF TGFLLYHDTN DYKDDDDK|
|Purity||> 98 % as determined by densitometric image analysis|
|Buffer||0.05M Phosphate buffer, 0.075M NaCl, pH 7.4|
|Bioactivity||Full-length adiponectin has been shown to activate AMP-activated protein kinase in hepatocyte. It can also activate AMPK in HepG2 human hepatocytes at the concentration of as low as 1.0 µg/ml. In vitro gluconeogenesis assay in primary rat hepatocytes was performed, showing the murine adiponectin derived from mammalian cells can inhibit glucose production.|
|Reconstitution||Add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely.|
|Preparation||Lyophilized (0.4µm filtered) purified protein|
|Synonyms||30kDa; Acdc; Acrp30; Ad; adipo; apM1; APN; GBP28|
|The use of this Proteins has been cited in the following citations:|
Adiponectin and its receptors are expressed in bone-forming cells.
,Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, Syversen U, Reseland JE,
,PubMed ID 15454091
Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality.
,Teoh H, Quan A, Bang KW, Wang G, Lovren F, Vu V, Haitsma JJ, Szmitko PE, Al-Omran M, Wang CH, Gupta M, Peterson MD, Zhang H, Chan L, Freedman J, Sweeney G, Verma S,
Am. J. Physiol. Endocrinol. Metab. 2018
,PubMed ID 18628355
Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.
,Wang Y, Lam JB, Lam KS, Liu J, Lam MC, Hoo RL, Wu D, Cooper GJ, Xu A,
Cancer Res. 2016
,PubMed ID 17145894
Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes.
,Conde J, Gomez R, Bianco G, Scotece M, Lear P, Dieguez C, Gomez-Reino J, Lago F, Gualillo O,
Ann. Rheum. Dis. 2016
,PubMed ID 21216818
Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice.
,Xu A, Yin S, Wong L, Chan KW, Lam KS,
,PubMed ID 14592951
Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice.
,Shore SA, Terry RD, Flynt L, Xu A, Hug C,
J. Allergy Clin. Immunol. 2012
,PubMed ID 16890763
Involvement of endothelial apoptosis underlying chronic obstructive pulmonary disease-like phenotype in adiponectin-null mice: implications for therapy.
,Nakanishi K, Takeda Y, Tetsumoto S, Iwasaki T, Tsujino K, Kuhara H, Jin Y, Nagatomo I, Kida H, Goya S, Kijima T, Maeda N, Funahashi T, Shimomura I, Tachibana I, Kawase I,
Am. J. Respir. Crit. Care Med. 2011
,PubMed ID 21239691
Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling.
,Medoff BD, Okamoto Y, Leyton P, Weng M, Sandall BP, Raher MJ, Kihara S, Bloch KD, Libby P, Luster AD,
Am. J. Respir. Cell Mol. Biol. 2009
,PubMed ID 19168697
Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner.
,Wang Y, Lam KS, Xu JY, Lu G, Xu LY, Cooper GJ, Xu A,
J. Biol. Chem. 2006
,PubMed ID 15734737
|AR09000PU-N||Recombinant mouse adiponectin, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.||
|TP721158||Purified recombinant protein of Mouse adiponectin, C1Q and collagen domain containing (Adipoq)||
|SA6051||Recombinant Adipocyte complement-related Protein (Mouse): The globular domain of adiponectin/acrp30 (amino acid residues, 111-247, gAcrp30) was overexpressed in E.coli and purified by using conventional chromatography techniques.||
|TP723007||Purified recombinant protein of Mouse adiponectin, C1Q and collagen domain containing (Adipoq).||
|SA6051X||Recombinant Adipocyte complement-related Protein (Mouse): The globular domain of adiponectin/acrp30 (amino acid residues, 111-247, gAcrp30) was overexpressed in E.coli and purified by using conventional chromatography techniques.||
|TP723120||Purified recombinant protein of Mouse adiponectin, C1Q and collagen domain containing (Adipoq).||
|AR09000PU-S||Recombinant mouse adiponectin, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.||