PDGFA (PDGF-AA)

CAT#: DA3551

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Recombinant Human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids). Range: 0.2-10.0 ng/ml


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USD 180.00


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2 Weeks

Size
    • 5 ug


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Product Data
Description Recombinant Human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids). Range: 0.2-10.0 ng/ml
Species Human
Expression Host E. coli
Predicted MW 28.5 kDa
Purity > 95 % pure by SDS-PAGE and visualised by silver stain.
Buffer 50 mM Acetic Acid
Bioactivity > 1 x 10e6 units/mg. The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is < 1 ng/ml.
Endotoxin < 0.1 ng per µg of PDGF-AA
Preparation Lyophilized purified fraction.
Reference Data
RefSeq NP_002598
Locus ID 5154
Cytogenetics 7p22.3
Synonyms PDGF-A; PDGF1
Summary This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Protein Families Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton

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68 Mouse Clones