Flt3 ligand

CAT#: DA3543X

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Flt3-ligand produced in E. coli is a soluble non-glycosylated 17.6 kDa polypeptide containing 155 amino acid residues which comprises the extracellular domain of the transmembrane flt3-ligand protein.


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2 Weeks

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    • 50 ug


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Specifications

Product Data
Description Flt3-ligand produced in E. coli is a soluble non-glycosylated 17.6 kDa polypeptide containing 155 amino acid residues which comprises the extracellular domain of the transmembrane flt3-ligand protein.
Species Human
Expression Host E. coli
Predicted MW 17.6 kDa
Purity > 98 % by RP-HPLC, Anion-exchange FPLC, Silverstain
Bioactivity Human rh Flt3-ligand is fully biologically active when compared to standards.
The ED50 range is 0.5-1.0 ng/ml corresponding to a specific activity of 1-2MUnits/mg, calculated by the dose-dependant stimulation of the proliferation of Human OCMI-AML5 cells.
Endotoxin < 0.1 ng per µg (IEU/µg) of rh Flt3-Ligand
Reconstitution Recombinant Flt3-Ligand is soluble in water and most aqueous buffers.
Restore in water to a concentration not less than 0.1 mg/ml.
This solution can then be stored at 2-8°C for future use or diluted into other buffered solutions. Further dilutions should be made into buffer containing carrier protein or medium containing serum.
Preparation Lyophilized (freeze-dried) without stabilizer
Reference Data
RefSeq NP_001191431
Locus ID 2323
Cytogenetics 19q13.33
Synonyms FL; FLG3L; FLT3L
Summary Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]). [supplied by OMIM, Jan 2011]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer

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68 Mouse Clones