VEGFR-3 / Flt-4 (Fc Chimera) Human Protein

CAT#: DA3536X

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VEGFR-3 / Flt-4 (Fc Chimera) human recombinant protein, 50 µg


Product Datasheet for 'DA3536X'


USD 365.00


Availability*
2 Weeks

Size
    • 50 ug


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Specifications

Product Data
Description VEGFR-3 / Flt-4 (Fc Chimera) human recombinant protein, 50 µg
Species Human
Expression Host Insect
Predicted MW 260 kDa
Purity >90% by SDS-PAGE and visualised by silver stain.
Buffer Presentation State: Purified
State: Lyophilized purified protein.
Buffer System: PBS without stabilizers.
Bioactivity Biological: Measured by its ability to bind recombinant Rat VEGF-C in a functional solid phase binding assay.
Immobilised recombinant Human sVEGFR-3/Fc at 5 µg/ml can bind recombinant Rat VEGF-C in a linear range of 8-500 ng/ml.
Endotoxin < 0.1 ng per µg of sVEGFR-3/Fc
Reconstitution Restore in PBS or medium to a concentration not lower than 100 µg/ml.
The lyophilised sVEGFR-3/Fc is soluble in water and most aqueous buffers.
Preparation Lyophilized purified protein.
Protein Description Recombinant Human soluble Vascular Endothelial Growth Factor Receptor-3 (sVEGFR-3) was fused with the Fc part of human IgG1. The recombinant mature sVEGFR-3/Fc is a disulfide-linked homodimeric protein. The sVEGFR-3/Fc monomers have a mass of approximately 130 kDa. The soluble receptor protein consists of all 7 extracellular domains (Met1-Glu774).
Note Centrifuge vials before opening!
Storage Store lyophilized at -20°C to -70°C.
Reconstituted sVEGFR-3/Fc should be stored in working aliquots at -20°C.
Avoid repeated freeze-thaw cycles!
Stability Shelf life: One year from despatch.
Reference Data
RefSeq NP_001341918
Locus ID 2324
Cytogenetics 5q35.3
Synonyms FLT-4; FLT41; LMPH1A; LMPHM1; PCL; VEGFR-3; VEGFR3
Summary This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Focal adhesion

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