BMP2 / BMP2A

CAT#: DA3502X

Reviews ()
Write a review

Human Bone Morphogenetic Protein-2 (BMP-2) is a disulfide-bonded homodimeric protein.
BMP-2 lacks the natural N-terminus which results in a 15-20 fold increase of specific activity.
The amino acid sequence of recombinant Human BMP-2 starts with MQAKHKQ (position 283) containing the Met from the E. coli expression vector.


 Product Datasheet for 'DA3502X'

  View other "BMP2" proteins (12)

USD 380.00


Availability*
2 Weeks

Size
    • 25 ug


Product images

Specifications

Product Data
Description Human Bone Morphogenetic Protein-2 (BMP-2) is a disulfide-bonded homodimeric protein.
BMP-2 lacks the natural N-terminus which results in a 15-20 fold increase of specific activity.
The amino acid sequence of recombinant Human BMP-2 starts with MQAKHKQ (position 283) containing the Met from the E. coli expression vector.
Species Human
Expression Host E. coli
Predicted MW 26 kDa
Purity > 95 % pure by SDS-PAGE and visualised by silver stain
Buffer 50mM Acetic Acid
Bioactivity 2.5 x 103 units/mg Measured by the ability of BMP-2 to induce Alkaline Phosphatase production by C2C12 myogenic cells.
The ED50 for this effect is typically 0.3-0.8 µg/ml.
Endotoxin < 0.1 ng per µg of BMP-2
Reconstitution The lyophilized BMP-2 is best soluble in 50 mM Acetic Acid and at a concentration of 0.1 mg/ml but should be also soluble in most aqueous buffers when the pH is below 6.0
Preparation Lyophilized purified Ig fraction
Reference Data
RefSeq NP_001191
Locus ID 650
Cytogenetics 20p12.3
Synonyms BDA2; BMP2A; SSFSC
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transmembrane
Protein Pathways Basal cell carcinoma, Cytokine-cytokine receptor interaction, Hedgehog signaling pathway, Pathways in cancer, TGF-beta signaling pathway

Documents

Other Versions

Other products for "BMP2"
Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
68 Mouse Clones