Cardiac Troponin I Human Protein

CAT#: BA627

Cardiac Troponin I human protein, 10 µg

Specifications

Product Data

• Species: Human
• Protein Source: Cardiac muscle
• Concentration: lot specific
• Purity: >95% by SDS-PAGE
• Buffer: State: Liquid
  Buffer System: 7M Urea, 5 mM EDTA, 20 mM Tris
  Preservative: 15 mM Mercaptoethanol
• Preparation: Liquid
• Applications: ELISA.
• Protein Description: Purified native Human Troponin I from Human heart
• Note: Caution: Blood samples of the tissue donor for this product was tested and found negative for HBsAg, HCV, syphillis and HIV-I and HIV-II antibodies. Nevertheless, all products from human sources should be handled as potentially infectious.
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_000354
• Locus ID: 7137
• Cytogenetics: 19q13.42
• Synonyms: CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1
• Summary: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020]
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency
• Protein Pathways: Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)