KLKB1 / Kininogen

USD 250.00


Availability*
5 Days

Size
    • 50 ug


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Specifications

Product Data
Description Purified Human Plasma Kallikrein.
Species Human
Expression Host Plasma
Concentration 0.518 mg/ml (prior to lyophilization) (OD280nm, E1%=10.6)
Purity > 95 % pure by SDS-PAGE.
Buffer 20mM Tris-HCl, pH 7.8 containing 100 mM Sodium Chloride without preservatives.
Bioactivity > / = 15 units per mg. One unit is defined as the amount of enzyme that will hydrolyze 1 µmole of D-Pro-Phe-Arg-pNA (Chromogenix S-2303) per minute at 25°C, pH 7.8.
Reconstitution Restore with 96.5 µl distilled water.
Preparation Lyophilized purified protein.
Reference Data
RefSeq NP_000883
Locus ID 3818
Cytogenetics 4q35.2
Synonyms KLK3; PKK; PKKD; PPK
Summary This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Protein Families Druggable Genome, Protease
Protein Pathways Complement and coagulation cascades

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68 Mouse Clones