Neurofilament H (200 kD) Bovine Protein
Neurofilament H (200 kD) bovine protein, 0.1 mg
|Description||Neurofilament H (200 kD) bovine protein, 0.1 mg|
|Protein Source||Spinal Cord|
|Predicted MW||200 kDa|
|Concentration||Protein concentration 1 mg/ml (according to Bradford)|
|Purity||>98% (determined by SDS gelelectrophoresis)|
|Buffer||Presentation State: Purified
|Reconstitution||BA1014: Restore with 200 µl distilled water (final volume 250 μl).
BA1014S: Restore with 80 µl distilled water (final volume 100 µl).
Final solution: 10mM Sodium Phosphate, pH 7.5, 2mM DTT, 6M Urea, 1 mM EDTA.
|Applications||Protein standard in 1D and 2D SDS gelelectrophoresis.
|Protein Description||Bovine Neurofilament 200 kDa|
|Note||Isoelectric Point: pI 5.5
Suitable to rebuild protofilaments and filaments under conditions of reconstitution.
|Storage||Store at 2-8°C (lyophilized) or at -20°C (reconstituted).
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Summary||Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]|
|Protein Families||Druggable Genome|
|Protein Pathways||Amyotrophic lateral sclerosis (ALS)|