Cytokeratin 8 (KRT8) (NM_001256282) Human Recombinant Protein
Bovine keratin K8 (formerly also designated Cytokeratin 8).
|Description||Bovine keratin K8 (formerly also designated Cytokeratin 8).|
|Predicted MW||52 kDa|
|Purity||> 95 % (determined by SDS gelelectrophoresis)|
|Buffer||30mM Tris/HCI pH 8, 9M Urea, 2mM DTT, 2mM EDTA, 10mM Methylammonium Chloride.|
|Reconstitution||Restore with distilled water.
BA1007S: 70 µl (final volume 100 µl).
BA1007 : 175 µl (final volume 250 µl).
|Synonyms||CARD2; CK-8; CK8; CYK8; K2C8; K8; KO|
|Summary||This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]|
|Protein Families||Druggable Genome|