CD324 / Cadherin-1 (23-709, His-tag) Human Protein

SKU AR52034PU-N

CD324 / Cadherin-1 (23-709, His-tag) human protein, 0.25 mg

Product Data

• Species: Human
• Expression Host: Insect
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  QEPEPCHPGF DAESYTFTVP RRHLERGRVL GRVNFEDCTG RQRTAYFSLD TRFKVGTDGV ITVKRPLRFH NPQIHFLVYA WDSTYRKFST KVTLNTVGHH HRPPPHQASV SGIQAELLTF PNSSPGLRRQ KRDWVIPPIS CPENEKGPFP KNLVQIKSNK DKEGKVFYSI TGQGADTPPV GVFIIERETG WLKVTEPLDR ERIATYTLFS HAVSSNGNAV EDPMEILITV TDQNDNKPEF TQEVFKGSVM EGALPGTSVM EVTATDADDD VNTYNAAIAY TILSQDPELP DKNMFTINRN TGVISVVTTG LDRESFPTYT LVVQAADLQG EGLSTTATAV ITVTDTNDNP PIFNPTTYKG QVPENEANVV ITTLKVTDAD APNTPAWEAV YTILNDDGGQ FVVTTNPVNN DGILKTAKGL DFEAKQQYIL HVAVTNVVPF EVSLTTSTAT VTVDVLDVNE APIFVPPEKR VEVSEDFGVG QEITSYTAQE PDTFMEQKIT YRIWRDTANW LEINPDTGAI STRAELDRED FEHVKNSTYT ALIIATDNGS PVATGTGTLL LILSDVNDNA PIPEPRTIFF CERNPKPQVI NIIDADLPPN TSPFTAELTH GASANWTIQY NDPTQESIIL KPKMALEVGD YKINLKLMDN QNKDQVTTLE VSVCDCEGAA GVCRKAQPVE AGLQIPALEH HHHHH
• Tag: His-tag
• Predicted MW: 76.8 kDa
• Concentration: lot specific
• Purity: >90% by SDS – PAGE
• Presentation State: Purified
• Buffer: Presentation State: Purified; State: Liquid purified protein; Buffer System: Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
• Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Preparation: Liquid purified protein
• Storage: Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice

Reference Data

• RefSeq: NP_001304113
• Locus ID: 999
• UniProt ID: P12830
• Cytogenetics: 16q22.1
• Synonyms: Epithelial cadherin, E-cadherin, Uvomorulin, CAM 120/80, CDH1, CDHE, UVO
• Summary: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Adherens junction, Bladder cancer, Cell adhesion molecules (CAMs), Endometrial cancer, Melanoma, Pathogenic Escherichia coli infection, Pathways in cancer, Thyroid cancer