GSK3 beta (1-420, His-tag) Human Protein

CAT#: AR51976PU-N

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GSK3 beta (1-420, His-tag) human protein, 0.25 mg



USD 1,105.00


Availability*
2 Weeks

Size
    • 250 ug


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Specifications

Product Data
Description GSK3 beta (1-420, His-tag) human protein, 0.25 mg
Species Human
Expression Host Insect
Expression cDNA Clone or AA Sequence MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST HHHHHH
Tag His-tag
Predicted MW 47.5 kDa
Concentration 0.25 mg/ml (determined by absorbance at 280nm)
Purity >90% by SDS - PAGE
Buffer Presentation State: Purified
State: Liquid purified protein
Buffer System: Phosphate Buffered Saline (pH7.4) containing 0.5mM PMSF and 30% glycerol.
Endotoxin < 1.0 EU per 1 microgram of protein (determined by LAL method)
Preparation Liquid purified protein
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_001139628
Locus ID 2932
Cytogenetics 3q13.33
Synonyms glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta; GSK3beta isoform
Summary The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Alzheimer's disease, Axon guidance, Basal cell carcinoma, B cell receptor signaling pathway, Cell cycle, Chemokine signaling pathway, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Hedgehog signaling pathway, Insulin signaling pathway, Melanogenesis, Neurotrophin signaling pathway, Pathways in cancer, Prostate cancer, T cell receptor signaling pathway, Wnt signaling pathway

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