Beta-hexosaminidase alpha / HEXA (23-529, His-tag) Human Protein

CAT#: AR51933PU-S

Reviews ()
Write a review

Recombinant human HEXA, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.


Product Datasheet for 'AR51933PU-S'


USD 330.00


Availability*
2 Weeks

Size
    • 50 ug


Product images

Specifications

Product Data
Description Recombinant human HEXA, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Species Human
Expression Host Other
Expression cDNA Clone or AA Sequence LWPWPQNFQT SDQRYVLYPN NFQFQYDVSS AAQPGCSVLD EAFQRYRDLL FGSGSWPRPY LTGKRHTLEK NVLVVSVVTP GCNQLPTLES VENYTLTIND DQCLLLSETV WGALRGLETF SQLVWKSAEG TFFINKTEIE DFPRFPHRGL LLDTSRHYLP LSSILDTLDV MAYNKLNVFH WHLVDDPSFP YESFTFPELM RKGSYNPVTH IYTAQDVKEV IEYARLRGIR VLAEFDTPGH TLSWGPGIPG LLTPCYSGSE PSGTFGPVNP SLNNTYEFMS TFFLEVSSVF PDFYLHLGGD EVDFTCWKSN PEIQDFMRKK GFGEDFKQLE SFYIQTLLDI VSSYGKGYVV WQEVFDNKVK IQPDTIIQVW REDIPVNYMK ELELVTKAGF RALLSAPWYL NRISYGPDWK DFYIVEPLAF EGTPEQKALV IGGEACMWGE YVDNTNLVPR LWPRAGAVAE RLWSNKLTSD LTFAYERLSH FRCELLRRGV QAQPLNVGFC EQEFEQTHHH HHH
Tag His-tag
Predicted MW 59.2 kDa
Concentration 0.5 mg/ml (determined by absorbance at 280nm)
Purity > 90 % by SDS - PAGE.
Buffer Phosphate buffered saline (pH7.4).
Endotoxin < 1.0 Eu per 1 microgram of protein (determined by LAL method)
Preparation Liquid purified protein
Reference Data
RefSeq NP_000511
Locus ID 3073
Cytogenetics 15q23
Synonyms TSD
Summary This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Protein Families Druggable Genome
Protein Pathways Amino sugar and nucleotide sugar metabolism, Glycosaminoglycan degradation, Glycosphingolipid biosynthesis - ganglio series, Glycosphingolipid biosynthesis - globo series, Lysosome, Metabolic pathways, Other glycan degradation

Documents

Other products for "HEXA"
Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
68 Mouse Clones
Molbio tools