Complement factor D (21-253, His-tag)

CAT#: AR51918PU-N

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Recombinant human CFD, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.


Product Datasheet for 'AR51918PU-N'


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USD 1,105.00


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2 Weeks

Size
    • 250 ug


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Specifications

Product Data
Description Recombinant human CFD, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Species Human
Expression Host Other
Tag His-tag
Predicted MW 26.01 kDa
Concentration 1.0 mg/ml (determined by bradford assay)
Purity > 95 % by SDS - PAGE.
Buffer Phosphate buffered saline (pH7.4).
Endotoxin < 1.0 Eu per 1 microgram of protein (determined by LAL method)
Preparation Liquid purified protein
Reference Data
RefSeq NP_001304264
Locus ID 1675
Cytogenetics 19p13.3
Synonyms ADIPSIN; ADN; DF; PFD
Summary This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Complement and coagulation cascades

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68 Mouse Clones