Interleukin-17A (IL17A) (24-155, His-tag) Human Protein

CAT#: AR51903PU-N

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Interleukin-17A (IL17A) (24-155, His-tag) human recombinant protein, 0.25 mg



USD 1,105.00


Availability*
2 Weeks

Size
    • 250 ug


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Specifications

Product Data
Description Interleukin-17A (IL17A) (24-155, His-tag) human recombinant protein, 0.25 mg
Species Human
Expression cDNA Clone or AA Sequence GITIPRNPGC PNSEDKNFPR TVMVNLNIHN RNTNTNPKRS SDYYNRSTSP WNLHRNEDPE RYPSVIWEAK CRHLGCINAD GNVDYHMNSV PIQQEILVLR REPPHCPNSF RLEKILVSVG CTCVTPIVHH VAHHHHHH
Tag His-tag
Predicted MW 15.9 kDa
Concentration 0.25 mg/ml (determined by bradford assay)
Purity >90% by SDS - PAGE
Buffer Presentation State: Purified
State: Liquid purified protein
Buffer System: Phosphate buffered saline (pH 7.4) containing 20% glycerol, 1mM EDTA, 0.1mM PMSF.
Endotoxin < 1.0 Eu per 1 microgram of protein (determined by LAL method)
Preparation Liquid purified protein
Protein Description Recombinant human IL17A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_002181
Locus ID 3605
Cytogenetics 6p12.2
Synonyms CTLA-8; CTLA8; IL-17; IL-17A; IL17
Summary The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction

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