PDGFB (82-190, His-tag) Human Protein

CAT#: AR51827PU-S

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Recombinant human PDGFB, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.


Product Datasheet for 'AR51827PU-S'


USD 415.00


Availability*
2 Weeks

Size
    • 50 ug


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Product Data
Description Recombinant human PDGFB, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MGSSHHHHHH SSGLVPRGSH MCKTRTEVFE ISRRLIDRTN ANFLVWPPCV EVQRCSGCCN NRNVQCRPTQ VQLRPVQVRK IEIVRKKPIF KKATVTLEDH LACKCETVAA ARPVTRSPGG SQEQRAKTPQ
Tag His-tag
Predicted MW 14.7 kDa
Concentration 0.25 mg/ml (determined by Bradford assay)
Purity > 95 % by SDS - PAGE
Buffer Phosphate buffer saline (pH 7.4) containing 10% glycerol.
Preparation Liquid purified protein
Reference Data
RefSeq NP_002599
Locus ID 5155
Cytogenetics 22q13.1
Synonyms c-sis; IBGC5; PDGF-2; PDGF2; SIS; SSV
Summary This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Protein Families Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma

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